Does Breztri Cause Weight Gain?

Breztri and weight gain

Does the Breztri Aerosphere inhaler cause weight gain? No, weight gain is not a side effect reported in Breztri Aerosphere’s clinical trials.

Breztri Aerosphere is a chronic obstructive pulmonary disease (COPD) prescription medication. It contains three active ingredients: budesonide, glycopyrrolate, and formoterol fumarate. These ingredients help in weight gain.

These drugs reduce inflammation, relax the airways, and improve breathing. You may wonder if Breztri Aerosphere can cause weight gain or loss if you have COPD.

What are the common side effects of Breztri Aerosphere?

side effects of Breztri Aerosphere

Like any medication, Breztri Aerosphere can cause some side effects and not add to the weight. The most common ones include:

  • Upper respiratory infections, including the common cold
  • Pneumonia
  • Back pain
  • Muscle spasms
  • Oral thrush, a fungal infection that affects the mouth,

Certain side effects could be mild and temporary, whereas others might be more severe, necessitating medical attention. You should always tell your doctor if you experience any side effects while using Breztri Aerosphere.

How to manage or prevent the side effects of Breztri Aerosphere?

Some of the side effects of Breztri Aerosphere can be  prevented by following these tips:

  • Rinse your mouth with water after each use of the inhaler. This can help prevent oral thrush and hoarseness.
  • Use a spacer device or a valved holding chamber with your inhaler. This can help deliver the medication more effectively to your lungs
  • and reduce the risk of throat irritation and coughing.
  • Avoid smoking and exposure to secondhand smoke. This can worsen your COPD symptoms and increase the risk of infections and pneumonia.
  • Drink plenty of fluids and stay hydrated. This can help thin the mucus in your airways and make coughing easier.
  • Get vaccinated against influenza and pneumococcal disease. This can help protect you from serious complications of these infections.

Read also: Does Famotidine Make You Gain Weight?

Can you stop taking Breztri Aerosphere?

It would be best to stop taking Breztri Aerosphere without consulting your doctor first. Stopping the medication abruptly can cause your COPD symptoms to worsen or lead to withdrawal effects, such as:

  • Fatigue
  • Weakness
  • Headache
  • Nausea
  • Dizziness
  • Low blood pressure
  • Low blood sugar

Before discontinuing Breztri Aerosphere entirely, your doctor might recommend gradually decreasing your dosage. You should follow your doctor’s instructions carefully and never change your amount or frequency of use without their approval.

How to use Breztri Aerosphere correctly?

To get the best results from Breztri Aerosphere, you should use it exactly as your doctor prescribes. Here are some general guidelines on how to use it correctly:

  • Use one inhalation twice a day, in the morning and the evening.
  • Do not use more than one inhalation in 12 hours.
  • Use up to two inhalations in 24 hours.
  • Do not use Breztri Aerosphere as a rescue inhaler for sudden breathing problems. Use a separate fast-acting inhaler for that purpose.
  • Shake the inhaler well before each use.
  • Breathe out fully before placing the mouthpiece in your mouth.
  • Press down on the top of the inhaler while breathing deeply and slowly through your mouth.
  • Hold your breath for about 10 seconds or as long as you are comfortable after inhaling the medication.
  • Breathe out slowly through either your nose or mouth.
  • Repeat these steps if you need a second inhalation.

What are the interactions of Breztri Aerosphere with other drugs or foods?

Breztri Aerosphere can interact with other drugs or foods, affecting how it works or increasing the risk of side effects. Breztri Aerosphere can interact with certain substances, such as:

  • Other medications contain beta-agonists, anticholinergics, or corticosteroids. These can increase the effects or side effects of Breztri Aerosphere.
  • Medications that affect the heart rhythm include quinidine, procainamide, amiodarone, sotalol, and others. These can increase the risk of irregular heartbeat or low potassium levels when used with Breztri Aerosphere.
  • Medications that affect the metabolism of Breztri Aerosphere, such as ketoconazole, erythromycin, clarithromycin, ritonavir, and others. These can increase the blood levels of Breztri Aerosphere and its side effects.
  • Grapefruit juice. This can also increase the blood levels of Breztri Aerosphere and its side effects.

Before using Breztri Aerosphere, informing your doctor about all your medications, supplements, and herbal products would be beneficial. Furthermore, avoiding consuming grapefruit juice while using Breztri Aerosphere is advisable. You should check with your doctor or pharmacist before starting or stopping any new medications while using Breztri Aerosphere.

Talk to Your Doctor to Learn More About Side Effects

Does Breztri cause weight gain?

The answer is no. Weight gain is not a side effect of using Breztri Aerosphere. Budesonide, one of the ingredients in Breztri Aerosphere, can cause weight loss by affecting adrenal function.

However, weight changes can occur in people with COPD for various reasons, such as:

  • Loss of muscle mass due to reduced physical activity and oxygen delivery
  • Increased appetite due to increased energy expenditure and inflammation
  • Fluid retention due to heart failure or steroid use
  • Depression or anxiety can affect eating habits

Therefore, monitoring your weight regularly and reporting any significant changes to your doctor is important. Your doctor may recommend some strategies to help you maintain a healthy weight, such as:

  • Eat a well-balanced diet with enough protein, fiber, fruits, and vegetables.
  • Drink enough water and limit salt intake to prevent fluid retention.
  • Avoid alcohol and caffeine that can dehydrate you and worsen your COPD symptoms.
  • Exercise regularly as tolerated and under your doctor’s guidance.
  • Join a pulmonary rehabilitation program that can help you improve your breathing, strength, and endurance.
  • Seek counseling or support groups if you are feeling depressed or anxious.

How long does Breztri stay in your system?

There needs to be more information available on how long Breztri stays in your system. However, it is recommended to safely throw Breztri Aerosphere away 3 months after you open the foil pouch (for a 120-inhalation canister) or when the dose counter reads “0,” whichever comes first.

The active ingredients in Breztri Aerosphere have different half-lives, which means the time it takes for half of the drug to be eliminated from your body. According to the prescribing information, the half-lives of budesonide, glycopyrrolate, and formoterol fumarate are:

  • Budesonide: about 2 to 3 hours
  • Glycopyrrolate: about 5 hours
  • Formoterol fumarate: about 10 hours

This means it may take several hours to days for these drugs to completely clear from your system. However, this may vary depending on age, weight, metabolism, kidney function, liver function, and other factors.

Breztri vs. Trelegy

Breztri Aerosphere and Trelegy Ellipta are triple-therapy combination inhalers used for the long-term treatment of COPD in adults. They contain three active ingredients that reduce inflammation, relax the airways, and improve breathing.

However, there are some differences between these two inhalers, such as:

  • The active ingredients. Breztri Aerosphere contains budesonide (an inhaled corticosteroid), glycopyrrolate (an anticholinergic), and formoterol fumarate (a long-acting beta agonist). Trelegy Ellipta contains fluticasone furoate (an inhaled corticosteroid), umeclidinium (an anticholinergic), and vilanterol (a long-acting beta agonist).
  • The dosage form. Breztri Aerosphere is an aerosol inhaler that delivers a fine mist of medication into your lungs. Trelegy Ellipta is a dry powder inhaler with a fine drug in your lungs.
  • The dosing schedule. Breztri Aerosphere is used twice a day (one inhalation in the morning and one inhalation in the evening). Trelegy Ellipta is used once daily (one inhalation simultaneously daily).
  • The side effects. Both inhalers can cause similar side effects, such as upper respiratory infections, pneumonia, oral thrush, back pain, muscle spasms, cough, hoarseness, and sinusitis. However, some side effects may be more common or severe with one inhaler than the other. For example, Trelegy Ellipta may cause more bone loss or eye problems than Breztri Aerosphere.
    The interactions. Both inhalers can interact with other drugs or foods that can affect how they work or increase the risk of side effects.
  • Interactions may be more significant with one inhaler than the other. For example, grapefruit juice can elevate the blood levels of Breztri Aerosphere but does not have the same effect on Trelegy Ellipta.

Your doctor will prescribe the inhaler best suited for your condition and preferences. You should consult your doctor before you switch between these two inhalers.


Breztri Aerosphere is a medication that can help you manage your COPD symptoms and improve your quality of life. However, it can also cause some side effects you should be aware of.

Weight gain is not one of them, but weight changes can occur in people with COPD for other reasons. You should always follow your doctor’s instructions on how to use Breztri Aerosphere correctly and safely.

You should also monitor your weight regularly and report any significant changes to your doctor. By doing so, you can optimize the benefits of Breztri Aerosphere and minimize the risks.

Recommended for you: Diet Plan For Weight Gain

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